6D8E

Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor

6D8E の概要

• エントリーDOI: 10.2210/pdb6d8e/pdb
• 分子名称: Epidermal growth factor receptor, (4-fluorophenyl)methyl {2-[(1-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate (3 entities in total)
• 機能のキーワード: egfr, inhibitor, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37793.63

構造登録者

Park, E.,Eck, M.J. (登録日: 2018-04-26, 公開日: 2018-07-18, 最終更新日: 2023-10-04)

• 主引用文献: Jang, J.,Son, J.,Park, E.,Kosaka, T.,Saxon, J.A.,De Clercq, D.J.H.,Choi, H.G.,Tanizaki, J.,Eck, M.J.,Janne, P.A.,Gray, N.S.; Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.; Angew. Chem. Int. Ed. Engl., 57:11629-11633, 2018; PubMed: 29978938; DOI: 10.1002/anie.201805187

実験手法

X-RAY DIFFRACTION (2.537 Å)