6D5W

Ras:SOS:Ras in complex with a small molecule activator

6D5W の概要

• エントリーDOI: 10.2210/pdb6d5w/pdb
• 分子名称: GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 95190.00

構造登録者

Phan, J.,Hodges, T.,Fesik, S.W. (登録日: 2018-04-19, 公開日: 2019-03-27, 最終更新日: 2023-10-04)

• 主引用文献: Hodges, T.R.,Abbott, J.R.,Little, A.J.,Sarkar, D.,Salovich, J.M.,Howes, J.E.,Akan, D.T.,Sai, J.,Arnold, A.L.,Browning, C.,Burns, M.C.,Sobolik, T.,Sun, Q.,Beesetty, Y.,Coker, J.A.,Scharn, D.,Stadtmueller, H.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,McConnell, D.B.,Fesik, S.W.; Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.; J. Med. Chem., 61:8875-8894, 2018; PubMed: 30205005; DOI: 10.1021/acs.jmedchem.8b01108

実験手法

X-RAY DIFFRACTION (2.478 Å)