6D49
Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution
Summary for 6D49
Entry DOI | 10.2210/pdb6d49/pdb |
Related | 6D48 6D4A |
Descriptor | Myeloid cell surface antigen CD33, GLYCEROL, 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | sialic acid binding, transmembrane, receptor, siglec, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32071.41 |
Authors | Hermans, S.J.,Miles, L.A.,Parker, M.W. (deposition date: 2018-04-17, release date: 2019-04-17, Last modification date: 2023-10-04) |
Primary citation | Miles, L.A.,Hermans, S.J.,Crespi, G.A.N.,Gooi, J.H.,Doughty, L.,Nero, T.L.,Markulic, J.,Ebneth, A.,Wroblowski, B.,Oehlrich, D.,Trabanco, A.A.,Rives, M.L.,Royaux, I.,Hancock, N.C.,Parker, M.W. Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19:110-118, 2019 Cited by PubMed: 31369984DOI: 10.1016/j.isci.2019.07.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.801 Å) |
Structure validation
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