6D1E

Crystal structure of NDM-1 complexed with compound 7

6D1E の概要

• エントリーDOI: 10.2210/pdb6d1e/pdb
• 分子名称: Metallo-beta-lactamase type 2, ZINC ION, [(5-methoxy-7-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, ... (5 entities in total)
• 機能のキーワード: beta-lactamase, carbapenemase, phosphonate, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25135.79

構造登録者

Pemberton, O.A.,Chen, Y. (登録日: 2018-04-11, 公開日: 2019-04-17, 最終更新日: 2023-10-04)

• 主引用文献: Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y.; Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.; J.Med.Chem., 62:8480-8496, 2019; PubMed: 31483651; DOI: 10.1021/acs.jmedchem.9b00728

実験手法

X-RAY DIFFRACTION (1.15 Å)