6D16

Crystal structure of KPC-2 complexed with compound 2

Summary for 6D16

Entry DOI	10.2210/pdb6d16/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, [(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	beta-lactamase, carbapenemase, phosphonate, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	31168.90
Authors	Pemberton, O.A.,Chen, Y. (deposition date: 2018-04-11, release date: 2019-04-17, Last modification date: 2023-10-04)
Primary citation	Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651 DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation