6D0E

X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13

6D0E の概要

• エントリーDOI: 10.2210/pdb6d0e/pdb
• 分子名称: Protease, (3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}butan-2-yl]carbamate (3 entities in total)
• 機能のキーワード: hiv-1 protease, protease inhibitor, darunavir, difluorophenyl, nonpeptidic, tmc-126, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22220.19

構造登録者

Yedidi, R.S.,Hayashi, H.,Ghosh, A.K.,Mitsuya, H. (登録日: 2018-04-10, 公開日: 2019-05-01, 最終更新日: 2023-10-04)

• 主引用文献: Amano, M.,Salcedo-Gomez, P.M.,Yedidi, R.S.,Zhao, R.,Hayashi, H.,Hasegawa, K.,Nakamura, T.,Martyr, C.D.,Ghosh, A.K.,Mitsuya, H.; Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications.; Antimicrob.Agents Chemother., 63:-, 2019; PubMed: 31061155; DOI: 10.1128/AAC.00466-19

実験手法

X-RAY DIFFRACTION (1.95 Å)