6CZH

Structure of a redesigned beta barrel, mFAP0, bound to DFHBI

Summary for 6CZH

Entry DOI	10.2210/pdb6czh/pdb
Descriptor	mFAP0, (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one (3 entities in total)
Functional Keywords	beta barrel, rossetta, computational, de novo, ligand binder, de novo protein
Biological source	synthetic construct
Total number of polymer chains	2
Total formula weight	24979.58
Authors	Doyle, L.A.,Stoddard, B.L. (deposition date: 2018-04-09, release date: 2018-09-19, Last modification date: 2024-03-13)
Primary citation	Dou, J.,Vorobieva, A.A.,Sheffler, W.,Doyle, L.A.,Park, H.,Bick, M.J.,Mao, B.,Foight, G.W.,Lee, M.Y.,Gagnon, L.A.,Carter, L.,Sankaran, B.,Ovchinnikov, S.,Marcos, E.,Huang, P.S.,Vaughan, J.C.,Stoddard, B.L.,Baker, D. De novo design of a fluorescence-activating beta-barrel. Nature, 561:485-491, 2018 Cited by PubMed: 30209393 DOI: 10.1038/s41586-018-0509-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation