6CYI
Grp94 N-domain bound to NEOCA
Summary for 6CYI
Entry DOI | 10.2210/pdb6cyi/pdb |
Descriptor | Endoplasmin, TRIETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | hsp90, grp94, endoplasmic reticulum, chaperone, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Canis lupus familiaris (Dog) |
Total number of polymer chains | 1 |
Total formula weight | 31874.66 |
Authors | Huck, J.D.,Aw, W.J.,Gewirth, D.T. (deposition date: 2018-04-05, release date: 2019-04-10, Last modification date: 2023-10-04) |
Primary citation | Huck, J.D.,Que, N.L.S.,Immormino, R.M.,Shrestha, L.,Taldone, T.,Chiosis, G.,Gewirth, D.T. NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294:16010-16019, 2019 Cited by PubMed: 31501246DOI: 10.1074/jbc.RA119.009960 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75658250614 Å) |
Structure validation
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