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6CUO

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6CUO
Entry DOI10.2210/pdb6cuo/pdb
DescriptorGTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
Functional Keywordsras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight95758.80
Authors
Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2018-03-26, release date: 2019-02-06, Last modification date: 2023-11-15)
Primary citationAbbott, J.R.,Patel, P.A.,Howes, J.E.,Akan, D.T.,Kennedy, J.P.,Burns, M.C.,Browning, C.F.,Sun, Q.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9:941-946, 2018
Cited by
PubMed: 30258545
DOI: 10.1021/acsmedchemlett.8b00296
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.73 Å)
Structure validation

217705

數據於2024-03-27公開中

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