6CTR

Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF (R & S isomers), beta, gamma dCTP analogue

6CTR の概要

• エントリーDOI: 10.2210/pdb6ctr/pdb
• 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3'), ... (11 entities in total)
• 機能のキーワード: dna polymerase beta, conformational change, enzyme mechanism, lfer, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 49159.54

構造登録者

Batra, V.K.,Wilson, S.H. (登録日: 2018-03-23, 公開日: 2018-06-20, 最終更新日: 2023-10-04)

• 主引用文献: Batra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.; Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.; Biochemistry, 57:3934-3944, 2018; PubMed: 29874056; DOI: 10.1021/acs.biochem.8b00418

実験手法

X-RAY DIFFRACTION (1.85 Å)