6CT2

MYST histone acetyltransferase KAT6A/B in complex with WM-1119

Summary for 6CT2

• Entry DOI: 10.2210/pdb6ct2/pdb
• Descriptor: Histone acetyltransferase KAT8, 3-fluoro-N'-[(2-fluorophenyl)sulfonyl]-5-(pyridin-2-yl)benzohydrazide, ZINC ION, ... (5 entities in total)
• Functional Keywords: complex, lysine acetyltransferases, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35011.82

Authors

Ren, B.,Peat, T.S. (deposition date: 2018-03-22, release date: 2018-08-01, Last modification date: 2018-08-22)

• Primary citation: Baell, J.B.,Leaver, D.J.,Hermans, S.J.,Kelly, G.L.,Brennan, M.S.,Downer, N.L.,Nguyen, N.,Wichmann, J.,McRae, H.M.,Yang, Y.,Cleary, B.,Lagiakos, H.R.,Mieruszynski, S.,Pacini, G.,Vanyai, H.K.,Bergamasco, M.I.,May, R.E.,Davey, B.K.,Morgan, K.J.,Sealey, A.J.,Wang, B.,Zamudio, N.,Wilcox, S.,Garnham, A.L.,Sheikh, B.N.,Aubrey, B.J.,Doggett, K.,Chung, M.C.,de Silva, M.,Bentley, J.,Pilling, P.,Hattarki, M.,Dolezal, O.,Dennis, M.L.,Falk, H.,Ren, B.,Charman, S.A.,White, K.L.,Rautela, J.,Newbold, A.,Hawkins, E.D.,Johnstone, R.W.,Huntington, N.D.,Peat, T.S.,Heath, J.K.,Strasser, A.,Parker, M.W.,Smyth, G.K.,Street, I.P.,Monahan, B.J.,Voss, A.K.,Thomas, T.; Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.; Nature, 560:253-257, 2018; PubMed: 30069049; DOI: 10.1038/s41586-018-0387-5

Experimental method

X-RAY DIFFRACTION (2.128 Å)