6CNZ

Crystal Structure of Chorismate Mutase from Burkholderia thailandensis

Replaces:  4OJ7

Summary for 6CNZ

• Entry DOI: 10.2210/pdb6cnz/pdb
• Descriptor: Chorismate mutase, NITRATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: ssgcid, chorismate mutase, structural genomics, seattle structural genomics center for infectious disease, isomerase
• Biological source: Burkholderia thailandensis
• Total number of polymer chains: 6
• Total formula weight: 117777.24

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2018-03-09, release date: 2018-03-21, Last modification date: 2024-10-09)

Primary citation

Asojo, O.A.,Dranow, D.M.,Serbzhinskiy, D.,Subramanian, S.,Staker, B.,Edwards, T.E.,Myler, P.J.
Crystal structure of chorismate mutase from Burkholderia thailandensis.
Acta Crystallogr F Struct Biol Commun, 74:294-299, 2018

PubMed Abstract: Burkholderia thailandensis is often used as a model for more virulent members of this genus of proteobacteria that are highly antibiotic-resistant and are potential agents of biological warfare that are infective by inhalation. As part of ongoing efforts to identify potential targets for the development of rational therapeutics, the structures of enzymes that are absent in humans, including that of chorismate mutase from B. thailandensis, have been determined by the Seattle Structural Genomics Center for Infectious Disease. The high-resolution structure of chorismate mutase from B. thailandensis was determined in the monoclinic space group P2 with three homodimers per asymmetric unit. The overall structure of each protomer has the prototypical AroQγ topology and shares conserved binding-cavity residues with other chorismate mutases, including those with which it has no appreciable sequence identity.

PubMed: 29717997
DOI: 10.1107/S2053230X1800506X

Experimental method

X-RAY DIFFRACTION (2.15 Å)