6CNX

Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor

6CNX の概要

• エントリーDOI: 10.2210/pdb6cnx/pdb
• 分子名称: Serine/threonine-protein kinase VRK1, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 167517.21

構造登録者

Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC) (登録日: 2018-03-09, 公開日: 2018-04-04, 最終更新日: 2023-10-04)

• 主引用文献: Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Gama, F.,Azevedo, H.,Guimaraes, C.,Mascarello, A.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC); Crystal Structure of the Human Vaccinia-Related Kinase 1 (VRK1) bound to a N-propynyl-N-isopentil-dihydropteridine inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (2 Å)