6CIF

Structure of the human endothelial nitric oxide synthase heme domain in complex with N-(1-(Piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide

Summary for 6CIF

• Entry DOI: 10.2210/pdb6cif/pdb
• Descriptor: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (10 entities in total)
• Functional Keywords: nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 205499.25

Authors

Chreifi, G.,Li, H.,Poulos, T.L. (deposition date: 2018-02-23, release date: 2018-10-31, Last modification date: 2023-10-04)

• Primary citation: Li, H.,Evenson, R.J.,Chreifi, G.,Silverman, R.B.,Poulos, T.L.; Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.; Biochemistry, 57:6319-6325, 2018; PubMed: 30335983; DOI: 10.1021/acs.biochem.8b00895

Experimental method

X-RAY DIFFRACTION (2.2 Å)