6CIE

Structure of human endothelial nitric oxide synthase heme domain in complex with N-(1-(2-(Ethyl(methyl)amino)ethyl)-1,2,3,4-tetrahydroquino-lin-6-yl)thiophene-2-carboximidamide

Summary for 6CIE

Entry DOI	10.2210/pdb6cie/pdb
Descriptor	Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (10 entities in total)
Functional Keywords	nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	205571.48
Authors	Chreifi, G.,Li, H.,Poulos, T.L. (deposition date: 2018-02-23, release date: 2018-10-31, Last modification date: 2023-10-04)
Primary citation	Li, H.,Evenson, R.J.,Chreifi, G.,Silverman, R.B.,Poulos, T.L. Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides. Biochemistry, 57:6319-6325, 2018 Cited by PubMed: 30335983 DOI: 10.1021/acs.biochem.8b00895 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation