6CHI

Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide

6CHI の概要

• エントリーDOI: 10.2210/pdb6chi/pdb
• 分子名称: Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, 3-hydroxy-17-(3-pyridyl)-androst-5,16-dien-6-amide, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, p450, cyp17a1, p450c17, p450 17a1, monooxygenase, 17a-hydroxylase, heme protein, cytochrome p450 oxidoreductase, membrane, microsome, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 226996.65

構造登録者

Scott, E.E. (登録日: 2018-02-22, 公開日: 2018-06-06, 最終更新日: 2023-10-04)

• 主引用文献: Fehl, C.,Vogt, C.D.,Yadav, R.,Li, K.,Scott, E.E.,Aube, J.; Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.; J. Med. Chem., 61:4946-4960, 2018; PubMed: 29792703; DOI: 10.1021/acs.jmedchem.8b00419

実験手法

X-RAY DIFFRACTION (2.698 Å)