6CH8

Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22

Summary for 6CH8

• Entry DOI: 10.2210/pdb6ch8/pdb
• Descriptor: Envelope glycoprotein gp41, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (19 entities in total)
• Functional Keywords: env glycoprotein, broadly neutralizing antibodies, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 186605.89

Authors

Barnes, C.O.,Bjorkman, P.J. (deposition date: 2018-02-22, release date: 2018-05-02, Last modification date: 2023-10-04)

• Primary citation: Barnes, C.O.,Gristick, H.B.,Freund, N.T.,Escolano, A.,Lyubimov, A.Y.,Hartweger, H.,West, A.P.,Cohen, A.E.,Nussenzweig, M.C.,Bjorkman, P.J.; Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.; Nat Commun, 9:1251-1251, 2018; PubMed: 29593217; DOI: 10.1038/s41467-018-03632-y

Experimental method

X-RAY DIFFRACTION (4.1 Å)