6CH8

Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22

6CH8 の概要

• エントリーDOI: 10.2210/pdb6ch8/pdb
• 分子名称: Envelope glycoprotein gp41, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (19 entities in total)
• 機能のキーワード: env glycoprotein, broadly neutralizing antibodies, immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 186605.89

構造登録者

Barnes, C.O.,Bjorkman, P.J. (登録日: 2018-02-22, 公開日: 2018-05-02, 最終更新日: 2023-10-04)

• 主引用文献: Barnes, C.O.,Gristick, H.B.,Freund, N.T.,Escolano, A.,Lyubimov, A.Y.,Hartweger, H.,West, A.P.,Cohen, A.E.,Nussenzweig, M.C.,Bjorkman, P.J.; Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.; Nat Commun, 9:1251-1251, 2018; PubMed: 29593217; DOI: 10.1038/s41467-018-03632-y

実験手法

X-RAY DIFFRACTION (4.1 Å)