6CGP
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with MAIP-032
Summary for 6CGP
| Entry DOI | 10.2210/pdb6cgp/pdb |
| Descriptor | Hdac6 protein, POTASSIUM ION, ZINC ION, ... (6 entities in total) |
| Functional Keywords | histone deacetylase, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Danio rerio (Zebrafish) |
| Total number of polymer chains | 1 |
| Total formula weight | 40801.51 |
| Authors | Osko, J.D.,Christianson, D.W. (deposition date: 2018-02-20, release date: 2018-06-13, Last modification date: 2023-10-04) |
| Primary citation | Mackwitz, M.K.W.,Hamacher, A.,Osko, J.D.,Held, J.,Scholer, A.,Christianson, D.W.,Kassack, M.U.,Hansen, F.K. Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors. Org. Lett., 20:3255-3258, 2018 Cited by PubMed: 29790770DOI: 10.1021/acs.orglett.8b01118 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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