6CFM

Crystal Structure of the Human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor

Replaces:  6BW7

Summary for 6CFM

• Entry DOI: 10.2210/pdb6cfm/pdb
• Descriptor: Serine/threonine-protein kinase VRK1, CHLORIDE ION, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, ... (5 entities in total)
• Functional Keywords: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 165970.76

Authors

Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-15, release date: 2018-03-07, Last modification date: 2023-10-04)

• Primary citation: Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Azevedo, H.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC); Crystal Structure of the Human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)