6CEE

Crystal structure of fragment 3-(1-Methyl-2-oxo-1,2-dihydroquinoxalin-3-yl)propionic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

6CEE の概要

• エントリーDOI: 10.2210/pdb6cee/pdb
• 分子名称: Histone deacetylase 6, ZINC ION, 3-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acid, ... (5 entities in total)
• 機能のキーワード: histone deacetylase, hdac, hdac6, ubiquitin, structural genomics consortium, sgc, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q9UBN7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12361.07

構造登録者

Harding, R.J.,Halabelian, L.,Ferreira de Freitas, R.,Franzoni, I.,Ravichandran, M.,Lautens, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.M.,Structural Genomics Consortium (SGC) (登録日: 2018-02-11, 公開日: 2018-02-28, 最終更新日: 2023-10-04)

• 主引用文献: Ferreira de Freitas, R.,Harding, R.J.,Franzoni, I.,Ravichandran, M.,Mann, M.K.,Ouyang, H.,Lautens, M.,Santhakumar, V.,Arrowsmith, C.H.,Schapira, M.; Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.; J. Med. Chem., 61:4517-4527, 2018; PubMed: 29741882; DOI: 10.1021/acs.jmedchem.8b00258

実験手法

X-RAY DIFFRACTION (1.55 Å)