6CDT
Structure of Human Anaplastic Lymphoma Kinase Domain
Summary for 6CDT
Entry DOI | 10.2210/pdb6cdt/pdb |
Descriptor | ALK tyrosine kinase receptor (2 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36909.36 |
Authors | McTigue, M.,Deng, Y.L.,Liu, W.,Brooun, A. (deposition date: 2018-02-09, release date: 2019-02-20, Last modification date: 2023-10-04) |
Primary citation | Johnson, T.W.,Bolanos, B.,Brooun, A.,Gallego, R.A.,Gehlhaar, D.,Jalaie, M.,McTigue, M.,Timofeevski, S. Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase. ACS Med Chem Lett, 9:872-877, 2018 Cited by PubMed: 30258533DOI: 10.1021/acsmedchemlett.8b00348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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