6CD7

Crystal structure of APH(2")-IVa in complex with plazomicin

「6C0C」から置き換えられました

6CD7 の概要

• エントリーDOI: 10.2210/pdb6cd7/pdb
• 分子名称: APH(2'')-Id, CHLORIDE ION, (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-y l]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide, ... (4 entities in total)
• 機能のキーワード: structural genomics, center for structural genomics of infectious diseases, csgid, eukaryotic protein kinase-like fold, aminoglycoside phosphotransferase, kinase, transferase, aminoglycosides, plazomicin, antibiotic, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Enterococcus casseliflavus (Enterococcus flavescens)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71699.42

構造登録者

Stogios, P.J.,Evdokimova, E.,Dong, A.,Di Leo, R.,Savchenko, A.,Satchell, K.J.,Joachimiak, J.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2018-02-08, 公開日: 2018-02-28, 最終更新日: 2023-10-04)

• 主引用文献: Cox, G.,Ejim, L.,Stogios, P.J.,Koteva, K.,Bordeleau, E.,Evdokimova, E.,Sieron, A.O.,Savchenko, A.,Serio, A.W.,Krause, K.M.,Wright, G.D.; Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.; ACS Infect Dis, 4:980-987, 2018; PubMed: 29634241; DOI: 10.1021/acsinfecdis.8b00001

実験手法

X-RAY DIFFRACTION (1.53 Å)