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6CBY

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975

Summary for 6CBY
Entry DOI10.2210/pdb6cby/pdb
DescriptorN-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone, ... (4 entities in total)
Functional Keywordssmyd2 mtf9975 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytosol : Q9NRG4
Total number of polymer chains2
Total formula weight101174.22
Authors
Primary citationTaylor, A.P.,Swewczyk, M.,Kennedy, S.,Trush, V.V.,Wu, H.,Zeng, H.,Dong, A.,Ferreira de Freitas, R.,Tatlock, J.,Kumpf, R.A.,Wythes, M.,Casimiro-Garcia, A.,Denny, R.A.,Parikh, M.D.,Li, F.,Barsyte-Lovejoy, D.,Schapira, M.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Owen, D.R.
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
J.Med.Chem., 62:7669-7683, 2019
Cited by
PubMed: 31415173
DOI: 10.1021/acs.jmedchem.9b00112
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

217705

数据于2024-03-27公开中

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