6CAV

Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Dibekacin

Summary for 6CAV

• Entry DOI: 10.2210/pdb6cav/pdb
• Descriptor: Bifunctional AAC/APH, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: kinase, antibiotic, aminoglycoside, resistance, transferase, transferase-antibiotic complex
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 4
• Total formula weight: 147988.44

Authors

Caldwell, S.J.,Berghuis, A.M. (deposition date: 2018-02-01, release date: 2018-04-11, Last modification date: 2023-10-04)

• Primary citation: Caldwell, S.J.,Berghuis, A.M.; Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.; Antimicrob. Agents Chemother., 62:-, 2018; PubMed: 29661878; DOI: 10.1128/AAC.00202-18

Experimental method

X-RAY DIFFRACTION (2.6 Å)