6C8R

Loganic acid O-methyltransferase complexed with SAH and loganic acid

Summary for 6C8R

• Entry DOI: 10.2210/pdb6c8r/pdb
• Descriptor: Loganic acid O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, Loganic acid, ... (4 entities in total)
• Functional Keywords: methyltransferase, sabath, loganic acid, transferase
• Biological source: Catharanthus roseus (Madagascar periwinkle)
• Total number of polymer chains: 2
• Total formula weight: 87425.24

Authors

Petronikolou, N.,Nair, S.K. (deposition date: 2018-01-25, release date: 2018-02-07, Last modification date: 2023-10-04)

Primary citation

Petronikolou, N.,Hollatz, A.J.,Schuler, M.A.,Nair, S.K.
Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside.
Chembiochem, 19:784-788, 2018

PubMed Abstract: Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. Loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin and demonstrates stereospecificity for the (6S,7R) substrate. We have biochemically characterized this biocatalyst and elucidated the basis for its strict substrate specificity. These studies could help facilitate the design of new classes of monoterpenoid indole alkaloids of pharmaceutical interest.

PubMed: 29399933
DOI: 10.1002/cbic.201700679

Experimental method

X-RAY DIFFRACTION (1.951 Å)