6C8R

Loganic acid O-methyltransferase complexed with SAH and loganic acid

6C8R の概要

• エントリーDOI: 10.2210/pdb6c8r/pdb
• 分子名称: Loganic acid O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, Loganic acid, ... (4 entities in total)
• 機能のキーワード: methyltransferase, sabath, loganic acid, transferase
• 由来する生物種: Catharanthus roseus (Madagascar periwinkle)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87425.24

構造登録者

Petronikolou, N.,Nair, S.K. (登録日: 2018-01-25, 公開日: 2018-02-07, 最終更新日: 2023-10-04)

主引用文献

Petronikolou, N.,Hollatz, A.J.,Schuler, M.A.,Nair, S.K.
Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside.
Chembiochem, 19:784-788, 2018

PubMed Abstract: Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. Loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin and demonstrates stereospecificity for the (6S,7R) substrate. We have biochemically characterized this biocatalyst and elucidated the basis for its strict substrate specificity. These studies could help facilitate the design of new classes of monoterpenoid indole alkaloids of pharmaceutical interest.

PubMed: 29399933
DOI: 10.1002/cbic.201700679

実験手法

X-RAY DIFFRACTION (1.951 Å)