6C8Q

Crystal structure of NAD synthetase (NadE) from Enterococcus faecalis in complex with NAD+

6C8Q の概要

• エントリーDOI: 10.2210/pdb6c8q/pdb
• 分子名称: NH(3)-dependent NAD(+) synthetase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: nad, nade, amidotransferase, nh3 dependent, atp pyrophosphatase, ligase, structural genomics, niaid, national institute of allergy and infectious diseases, csgid, center for structural genomics of infectious diseases, transferase
• 由来する生物種: Enterococcus faecalis V583
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 248887.99

構造登録者

Stogios, P.J.,Skarina, T.,McChesney, C.,Grimshaw, S.,Kwon, K.,Anderson, W.F.,Satchell, K.J.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2018-01-25, 公開日: 2018-02-14, 最終更新日: 2025-06-18)

主引用文献

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, :e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

実験手法

X-RAY DIFFRACTION (2.583 Å)