6C6I
Crystal structure of a chimeric NDM-1 metallo-beta-lactamase harboring the IMP-1 L3 loop
Summary for 6C6I
Entry DOI | 10.2210/pdb6c6i/pdb |
Related | 4hl2 |
Descriptor | Metallo-beta-lactamase type 2 chimera, ZINC ION (3 entities in total) |
Functional Keywords | chimeric protein, ndm-1, zn-contaning protein, hydrolase |
Biological source | Klebsiella pneumoniae More |
Total number of polymer chains | 2 |
Total formula weight | 49937.34 |
Authors | Otero, L.,Giannini, E.,Klinke, S.,Palacios, A.,Mojica, M.,Bonomo, R.,Llarrull, L.,Vila, A. (deposition date: 2018-01-18, release date: 2018-10-17, Last modification date: 2023-10-04) |
Primary citation | Palacios, A.R.,Mojica, M.F.,Giannini, E.,Taracila, M.A.,Bethel, C.R.,Alzari, P.M.,Otero, L.H.,Klinke, S.,Llarrull, L.I.,Bonomo, R.A.,Vila, A.J. The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop. Antimicrob. Agents Chemother., 63:-, 2019 Cited by PubMed: 30348667DOI: 10.1128/AAC.01754-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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