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6C6I

Crystal structure of a chimeric NDM-1 metallo-beta-lactamase harboring the IMP-1 L3 loop

Summary for 6C6I
Entry DOI10.2210/pdb6c6i/pdb
Related4hl2
DescriptorMetallo-beta-lactamase type 2 chimera, ZINC ION (3 entities in total)
Functional Keywordschimeric protein, ndm-1, zn-contaning protein, hydrolase
Biological sourceKlebsiella pneumoniae
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Total number of polymer chains2
Total formula weight49937.34
Authors
Otero, L.,Giannini, E.,Klinke, S.,Palacios, A.,Mojica, M.,Bonomo, R.,Llarrull, L.,Vila, A. (deposition date: 2018-01-18, release date: 2018-10-17, Last modification date: 2023-10-04)
Primary citationPalacios, A.R.,Mojica, M.F.,Giannini, E.,Taracila, M.A.,Bethel, C.R.,Alzari, P.M.,Otero, L.H.,Klinke, S.,Llarrull, L.I.,Bonomo, R.A.,Vila, A.J.
The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63:-, 2019
Cited by
PubMed: 30348667
DOI: 10.1128/AAC.01754-18
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

217157

数据于2024-03-13公开中

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