6C5T
PPARg LBD bound to SR11023
Summary for 6C5T
| Entry DOI | 10.2210/pdb6c5t/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, 2-{4-[(5-{[(1R)-1-(3-cyclopropylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]phenyl}-2-methylpropanoic acid (3 entities in total) |
| Functional Keywords | peroxisome proliferator activated receptor gamma; pparg, nuclear receptor, inverse agonist, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 32073.29 |
| Authors | Bruning, J.B.,Frkic, R.L.,Griffin, P.R. (deposition date: 2018-01-16, release date: 2018-08-01, Last modification date: 2023-11-15) |
| Primary citation | Frkic, R.L.,Marshall, A.C.,Blayo, A.L.,Pukala, T.L.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B. PPAR gamma in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix. iScience, 5:69-79, 2018 Cited by PubMed: 30123887DOI: 10.1016/j.isci.2018.06.012 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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