6C5T

PPARg LBD bound to SR11023

6C5T の概要

• エントリーDOI: 10.2210/pdb6c5t/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-{4-[(5-{[(1R)-1-(3-cyclopropylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]phenyl}-2-methylpropanoic acid (3 entities in total)
• 機能のキーワード: peroxisome proliferator activated receptor gamma; pparg, nuclear receptor, inverse agonist, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32073.29

構造登録者

Bruning, J.B.,Frkic, R.L.,Griffin, P.R. (登録日: 2018-01-16, 公開日: 2018-08-01, 最終更新日: 2023-11-15)

• 主引用文献: Frkic, R.L.,Marshall, A.C.,Blayo, A.L.,Pukala, T.L.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B.; PPAR gamma in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.; iScience, 5:69-79, 2018; PubMed: 30123887; DOI: 10.1016/j.isci.2018.06.012

実験手法

X-RAY DIFFRACTION (2.75 Å)