6C2X

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-Br-6-Me-phenyldiketoacid

6C2X の概要

• エントリーDOI: 10.2210/pdb6c2x/pdb
• 分子名称: Malate synthase G, MAGNESIUM ION, (2S)-4-(2-bromo-6-methylphenyl)-2-hydroxy-4-oxobutanoic acid, ... (4 entities in total)
• 機能のキーワード: acetyltransferase, structural genomics, tb structural genomics consortium, tbsgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 80768.15

構造登録者

Krieger, I.V.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2018-01-09, 公開日: 2018-09-05, 最終更新日: 2023-10-04)

• 主引用文献: Ellenbarger, J.F.,Krieger, I.V.,Huang, H.L.,Gomez-Coca, S.,Ioerger, T.R.,Sacchettini, J.C.,Wheeler, S.E.,Dunbar, K.R.; Anion-pi Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.; J Chem Inf Model, 58:2085-2091, 2018; PubMed: 30137983; DOI: 10.1021/acs.jcim.8b00417

実験手法

X-RAY DIFFRACTION (2.6 Å)