6C2M

Crystal structure of HCV NS3/4A protease variant Y56H in complex with MK-5172

Summary for 6C2M

• Entry DOI: 10.2210/pdb6c2m/pdb
• Descriptor: NS3 protease, ZINC ION, (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-di oxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadec ino[11,12-b]quinoxaline-8-carboxamide, ... (5 entities in total)
• Functional Keywords: ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus
• Total number of polymer chains: 4
• Total formula weight: 86843.86

Authors

Matthew, A.N.,Schiffer, C.A. (deposition date: 2018-01-08, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Matthew, A.N.,Schiffer, C.A.; Clinical signature variant of HCV NS3/4A protease uses a novel mechanism to confer resistance; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.859 Å)