6C2M
Crystal structure of HCV NS3/4A protease variant Y56H in complex with MK-5172
6C2M の概要
エントリーDOI | 10.2210/pdb6c2m/pdb |
分子名称 | NS3 protease, ZINC ION, (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-di oxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadec ino[11,12-b]quinoxaline-8-carboxamide, ... (5 entities in total) |
機能のキーワード | ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Hepatitis C virus |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 86843.86 |
構造登録者 | |
主引用文献 | Matthew, A.N.,Schiffer, C.A. Clinical signature variant of HCV NS3/4A protease uses a novel mechanism to confer resistance To Be Published, |
実験手法 | X-RAY DIFFRACTION (1.859 Å) |
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