6C1V

MBD2 in complex with double-stranded DNA

Summary for 6C1V

DescriptorMethyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION, ... (5 entities in total)
Functional Keywordsmbd, dna-binding, structural genomics, structural genomics consortium, sgc, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  Q9UBB5
Total number of polymer chains8
Total molecular weight327089.17
Authors
Lei, M.,Tempel, W.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2018-01-05, release date: 2018-02-14, Last modification date: 2018-05-23)
Primary citation
Liu, K.,Xu, C.,Lei, M.,Yang, A.,Loppnau, P.,Hughes, T.R.,Min, J.
Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293:7344-7354, 2018
PubMed: 29567833 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.001785
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.273100.5%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report