6C1R
Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist avacopan
Summary for 6C1R
Entry DOI | 10.2210/pdb6c1r/pdb |
Related | 6C1Q |
Related PRD ID | PRD_002303 |
Descriptor | Soluble cytochrome b562, C5a anaphylatoxin chemotactic receptor 1 chimera, PMX53, avacopan, ... (9 entities in total) |
Functional Keywords | gpcr, membrane protein-inhibitor complex, membrane protein/inhibitor |
Biological source | Escherichia coli More |
Total number of polymer chains | 2 |
Total formula weight | 51206.42 |
Authors | |
Primary citation | Liu, H.,Kim, H.R.,Deepak, R.N.V.K.,Wang, L.,Chung, K.Y.,Fan, H.,Wei, Z.,Zhang, C. Orthosteric and allosteric action of the C5a receptor antagonists. Nat. Struct. Mol. Biol., 25:472-481, 2018 Cited by PubMed: 29867214DOI: 10.1038/s41594-018-0067-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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