Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin

Summary for 6C06

Related6BZO 6C04 6C05
EMDB information7323
DescriptorDNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (9 entities in total)
Functional Keywordsinitiation, antibiotic, switch region inhibitor, transcription, transcription-antibiotic complex, transcription/antibiotic
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm  A0A045HD00
Total number of polymer chains7
Total molecular weight437917
Darst, S.A.,Campbell, E.A.,Boyaci Selcuk, H.,Chen, J.,Lilic, M. (deposition date: 2017-12-27, release date: 2018-03-28)
Primary citation
Boyaci, H.,Chen, J.,Lilic, M.,Palka, M.,Mooney, R.A.,Landick, R.,Darst, S.A.,Campbell, E.A.
Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7:-, 2018
PubMed: 29480804 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.34823
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers33637.3%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation report