6BYZ

Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocyclic Inhibitor 37

Summary for 6BYZ

• Entry DOI: 10.2210/pdb6byz/pdb
• Descriptor: Insulin-degrading enzyme, ALA-ALA-ALA, [(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-{[2-(trifluoromethyl)phenyl]sulfonyl}-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol, ... (5 entities in total)
• Functional Keywords: insulin, glucagon, diabetes, exo-site, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 237993.75

Authors

Tan, G.A.,Seeliger, M.A.,Maianti, J.P.,Liu, D.R. (deposition date: 2017-12-21, release date: 2019-04-03, Last modification date: 2023-10-04)

• Primary citation: Maianti, J.P.,Tan, G.A.,Vetere, A.,Welsh, A.J.,Wagner, B.K.,Seeliger, M.A.,Liu, D.R.; Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.; Nat.Chem.Biol., 15:565-574, 2019; PubMed: 31086331; DOI: 10.1038/s41589-019-0271-0

Experimental method

X-RAY DIFFRACTION (2.95624845742 Å)