6BWX の概要
| エントリーDOI | 10.2210/pdb6bwx/pdb |
| EMDBエントリー | 7300 7301 7302 |
| 分子名称 | VP2 (1 entity in total) |
| 機能のキーワード | parvovirus, protoparvovirus, virus like particle |
| 由来する生物種 | Bufavirus-1 |
| タンパク質・核酸の鎖数 | 60 |
| 化学式量合計 | 3694077.18 |
| 構造登録者 | |
| 主引用文献 | Ilyas, M.,Mietzsch, M.,Kailasan, S.,Vaisanen, E.,Luo, M.,Chipman, P.,Smith, J.K.,Kurian, J.,Sousa, D.,McKenna, R.,Soderlund-Venermo, M.,Agbandje-McKenna, M. Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy. Viruses, 10:-, 2018 Cited by PubMed Abstract: Bufavirus strain 1 (BuV1), a member of the genus of the , was first isolated from fecal samples of children with acute diarrhea in Burkina Faso. Since this initial discovery, BuVs have been isolated in several countries, including Finland, the Netherlands, and Bhutan, in pediatric patients exhibiting similar symptoms. Towards their characterization, the structures of virus-like particles of BuV1, BuV2, and BuV3, the current known genotypes, have been determined by cryo-electron microscopy and image reconstruction to 2.84, 3.79, and 3.25 Å, respectively. The BuVs, 65-73% identical in amino acid sequence, conserve the major viral protein, VP2, structure and general capsid surface features of parvoviruses. These include a core β-barrel (βB-βI), α-helix A, and large surface loops inserted between these elements in VP2. The capsid contains depressions at the icosahedral 2-fold and around the 5-fold axes, and has three separated protrusions surrounding the 3-fold axes. Structure comparison among the BuVs and to available parvovirus structures revealed capsid surface variations and capsid 3-fold protrusions that depart from the single pinwheel arrangement of the animal protoparvoviruses. These structures provide a platform to begin the molecular characterization of these potentially pathogenic viruses. PubMed: 29300333DOI: 10.3390/v10010022 主引用文献が同じPDBエントリー |
| 実験手法 | ELECTRON MICROSCOPY (2.84 Å) |
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