6BWP

Crystal structure of Deoxy Hemoglobin in complex with beta Cys93 modifying agent, TD3

6BWP の概要

• エントリーDOI: 10.2210/pdb6bwp/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: hemoglobin, antisickling, allosteric effector, td3, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64749.31

構造登録者

Musayev, F.N.,Safo, R.M.,Safo, M.K. (登録日: 2017-12-15, 公開日: 2018-01-03, 最終更新日: 2023-10-04)

• 主引用文献: Nakagawa, A.,Ferrari, M.,Schleifer, G.,Cooper, M.K.,Liu, C.,Yu, B.,Berra, L.,Klings, E.S.,Safo, R.S.,Chen, Q.,Musayev, F.N.,Safo, M.K.,Abdulmalik, O.,Bloch, D.B.,Zapol, W.M.; A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.; Mol. Pharm., 15:1954-1963, 2018; PubMed: 29634905; DOI: 10.1021/acs.molpharmaceut.8b00108

実験手法

X-RAY DIFFRACTION (1.7 Å)