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6BVK

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6BVK
Entry DOI10.2210/pdb6bvk/pdb
DescriptorGTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
Functional Keywordsras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total formula weight95872.00
Authors
Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2017-12-13, release date: 2018-10-24, Last modification date: 2019-05-01)
Primary citationAbbott, J.R.,Hodges, T.R.,Daniels, R.N.,Patel, P.A.,Kennedy, J.P.,Howes, J.E.,Akan, D.T.,Burns, M.C.,Sai, J.,Sobolik, T.,Beesetty, Y.,Lee, T.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 61:6002-6017, 2018
Cited by
PubMed: 29856609
DOI: 10.1021/acs.jmedchem.8b00360
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.799 Å)
Structure validation

217705

數據於2024-03-27公開中

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