6BVK

Ras:SOS:Ras in complex with a small molecule activator

6BVK の概要

分子名称GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
機能のキーワードras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
由来する生物種Homo sapiens (Human)
ポリマー鎖数3
分子量合計95872
構造登録者
Phan, J.,Abbott, J.,Fesik, S.W. (登録日: 2017-12-13, 公開日: 2018-10-24, 最終更新日: 2019-05-01)
主引用文献
Abbott, J.R.,Hodges, T.R.,Daniels, R.N.,Patel, P.A.,Kennedy, J.P.,Howes, J.E.,Akan, D.T.,Burns, M.C.,Sai, J.,Sobolik, T.,Beesetty, Y.,Lee, T.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 61:6002-6017, 2018
PubMed: 29856609 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acs.jmedchem.8b00360
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.799 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1794 0.1% 1.2% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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