6BT5

Human mGlu8 Receptor complexed with L-AP4

Summary for 6BT5

Entry DOI	10.2210/pdb6bt5/pdb
Descriptor	Metabotropic glutamate receptor 8, (2S)-2-amino-4-phosphonobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	mglur8, grm8, l-ap4, gene id: 2918, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Multi-pass membrane protein: O00222
Total number of polymer chains	2
Total formula weight	107819.47
Authors	Schkeryantz, J.M.,Chen, Q.,Ho, J.D.,Atwell, S.,Zhang, A.,Vargas, M.C.,Wang, J.,Monn, J.A.,Hao, J. (deposition date: 2017-12-05, release date: 2018-02-07, Last modification date: 2023-11-15)
Primary citation	Schkeryantz, J.M.,Chen, Q.,Ho, J.D.,Atwell, S.,Zhang, A.,Vargas, M.C.,Wang, J.,Monn, J.A.,Hao, J. Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity. Bioorg. Med. Chem. Lett., 28:612-617, 2018 Cited by PubMed: 29402739 DOI: 10.1016/j.bmcl.2018.01.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.92 Å)

Structure validation