6BT5

Human mGlu8 Receptor complexed with L-AP4

6BT5 の概要

• エントリーDOI: 10.2210/pdb6bt5/pdb
• 分子名称: Metabotropic glutamate receptor 8, (2S)-2-amino-4-phosphonobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: mglur8, grm8, l-ap4, gene id: 2918, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: O00222
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107819.47

構造登録者

Schkeryantz, J.M.,Chen, Q.,Ho, J.D.,Atwell, S.,Zhang, A.,Vargas, M.C.,Wang, J.,Monn, J.A.,Hao, J. (登録日: 2017-12-05, 公開日: 2018-02-07, 最終更新日: 2023-11-15)

• 主引用文献: Schkeryantz, J.M.,Chen, Q.,Ho, J.D.,Atwell, S.,Zhang, A.,Vargas, M.C.,Wang, J.,Monn, J.A.,Hao, J.; Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.; Bioorg. Med. Chem. Lett., 28:612-617, 2018; PubMed: 29402739; DOI: 10.1016/j.bmcl.2018.01.037

実験手法

X-RAY DIFFRACTION (2.92 Å)