Summary for 6BST
| Entry DOI | 10.2210/pdb6bst/pdb |
| Descriptor | DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), N~1~-(3-azaniumylpropyl)butane-1,4-diaminium, CALCIUM ION, ... (4 entities in total) |
| Functional Keywords | z-dna, ca2+, dna |
| Biological source | synthetic construct |
| Total number of polymer chains | 2 |
| Total formula weight | 3808.76 |
| Authors | LUO, Z.,DAUTER, Z. (deposition date: 2017-12-04, release date: 2017-12-20, Last modification date: 2023-10-04) |
| Primary citation | Luo, Z.,Dauter, Z. The crystal structure of Z-DNA with untypically coordinated Ca J. Biol. Inorg. Chem., 23:253-259, 2018 Cited by PubMed Abstract: DNA oligomer duplexes with alternating cytosines and guanines in their sequence tend to form helices of the Z-DNA type, where the sugar and phosphate backbone forms a left-handed helix in a zigzag fashion with a repeat of two successive Watson-Crick pairs of nucleotides. Z-DNA duplexes often crystallize in complexes with diverse metal ions interacting with polar DNA atoms in various ways. This work describes the high-resolution crystal structure of a Z-DNA d(CGCGCG) duplex in complex with Ca ions, unusually coordinated as an approximate pentagonal bipyramid by two neighboring guanines through their O6 and N7 atoms and a water molecule in the equatorial plane and a phosphate oxygen atom and another water molecule in the apical positions. PubMed: 29270817DOI: 10.1007/s00775-017-1526-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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