6BST

CRYSTAL STRUCTURE OF Z-DNA WITH UNTYPICALLY COORDINATED CA2+ ION

「6B01」から置き換えられました

6BST の概要

• エントリーDOI: 10.2210/pdb6bst/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), N~1~-(3-azaniumylpropyl)butane-1,4-diaminium, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: z-dna, ca2+, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3808.76

構造登録者

LUO, Z.,DAUTER, Z. (登録日: 2017-12-04, 公開日: 2017-12-20, 最終更新日: 2023-10-04)

主引用文献

Luo, Z.,Dauter, Z.
The crystal structure of Z-DNA with untypically coordinated Ca
J. Biol. Inorg. Chem., 23:253-259, 2018

PubMed Abstract: DNA oligomer duplexes with alternating cytosines and guanines in their sequence tend to form helices of the Z-DNA type, where the sugar and phosphate backbone forms a left-handed helix in a zigzag fashion with a repeat of two successive Watson-Crick pairs of nucleotides. Z-DNA duplexes often crystallize in complexes with diverse metal ions interacting with polar DNA atoms in various ways. This work describes the high-resolution crystal structure of a Z-DNA d(CGCGCG) duplex in complex with Ca ions, unusually coordinated as an approximate pentagonal bipyramid by two neighboring guanines through their O6 and N7 atoms and a water molecule in the equatorial plane and a phosphate oxygen atom and another water molecule in the apical positions.

PubMed: 29270817
DOI: 10.1007/s00775-017-1526-4

実験手法

X-RAY DIFFRACTION (1.45 Å)