6BO1

Mono-adduct formed after 3 days in the reaction of dichlorido(1,3-dimethylbenzimidazol-2-ylidene)(eta6-p-cymene)ruthenium(II) with HEWL

6BO1 の概要

• エントリーDOI: 10.2210/pdb6bo1/pdb
• 分子名称: Lysozyme C, SODIUM ION, dichloro(1,3-dimethyl-1H-benzimidazol-3-ium-2-yl)ruthenium, ... (4 entities in total)
• 機能のキーワード: metal-based, anticancer, ruthenium, nhc, carbene, lysozyme, metallodrug, benzimidazole, dimethylbenzimidazole, hydrolase
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14672.32

構造登録者

Sullivan, M.P.,Hartinger, C.G.,Goldstone, D.C. (登録日: 2017-11-17, 公開日: 2018-05-16, 最終更新日: 2024-10-23)

主引用文献

Sullivan, M.P.,Nieuwoudt, M.K.,Bowmaker, G.A.,Lam, N.Y.S.,Truong, D.,Goldstone, D.C.,Hartinger, C.G.
Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct.
Chem. Commun. (Camb.), 54:6120-6123, 2018

PubMed Abstract: The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(η6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre.

PubMed: 29713703
DOI: 10.1039/c8cc02433b

実験手法

X-RAY DIFFRACTION (1.24 Å)