6BNB

Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC

6BNB の概要

• エントリーDOI: 10.2210/pdb6bnb/pdb
• 分子名称: DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ... (4 entities in total)
• 機能のキーワード: protac, degrader, e3 ligase, crbn, ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 164830.06

構造登録者

Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,Ishoey, M.,He, Z.,Zhang, T.,Bradner, J.E.,Fischer, E.S. (登録日: 2017-11-16, 公開日: 2018-05-30, 最終更新日: 2023-11-15)

• 主引用文献: Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,He, Z.,Donovan, K.A.,An, J.,Safaee, N.,Jedrychowski, M.P.,Ponthier, C.M.,Ishoey, M.,Zhang, T.,Mancias, J.D.,Gray, N.S.,Bradner, J.E.,Fischer, E.S.; Plasticity in binding confers selectivity in ligand-induced protein degradation.; Nat. Chem. Biol., 14:706-714, 2018; PubMed: 29892083; DOI: 10.1038/s41589-018-0055-y

実験手法

X-RAY DIFFRACTION (6.343 Å)