6BN5

Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2

6BN5 の概要

• エントリーDOI: 10.2210/pdb6bn5/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one (3 entities in total)
• 機能のキーワード: shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q06124
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121235.48

構造登録者

Blacklow, S.C.,Stams, T.,Fodor, M.,LaRochelle, J.R. (登録日: 2017-11-16, 公開日: 2017-12-13, 最終更新日: 2023-10-04)

• 主引用文献: LaRochelle, J.R.,Fodor, M.,Ellegast, J.M.,Liu, X.,Vemulapalli, V.,Mohseni, M.,Stams, T.,Buhrlage, S.J.,Stegmaier, K.,LaMarche, M.J.,Acker, M.G.,Blacklow, S.C.; Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.; Bioorg. Med. Chem., 25:6479-6485, 2017; PubMed: 29089257; DOI: 10.1016/j.bmc.2017.10.025

実験手法