6BL1
Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd13
6BL1 の概要
エントリーDOI | 10.2210/pdb6bl1/pdb |
分子名称 | Isocitrate dehydrogenase [NADP] cytoplasmic, ISOCITRIC ACID, (6aS,7S,9S,10aS)-7-methyl-8-oxo-10a-phenyl-2-(phenylamino)-5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazoline-9-carbonitrile, ... (5 entities in total) |
機能のキーワード | dehydrogenase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 146386.28 |
構造登録者 | |
主引用文献 | Jakob, C.G.,Upadhyay, A.K.,Donner, P.L.,Nicholl, E.,Addo, S.N.,Qiu, W.,Ling, C.,Gopalakrishnan, S.M.,Torrent, M.,Cepa, S.P.,Shanley, J.,Shoemaker, A.R.,Sun, C.C.,Vasudevan, A.,Woller, K.R.,Shotwell, J.B.,Shaw, B.,Bian, Z.,Hutti, J.E. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J. Med. Chem., 61:6647-6657, 2018 Cited by PubMed: 30004704DOI: 10.1021/acs.jmedchem.8b00305 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.02 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード